Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus

Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus

The neuroprotective effect of l-kynurenine sulfate (KYN), a precursor of kynurenic acid (KYNA, a selective N-methyl-d-aspartate receptor antagonist), was studied. KYN (300 mg/kg i.p., applied daily for 5 days) appreciably decreased the number of injured pyramidal cells from 1850±100/mm2 to 1000±300/...

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Bibliographic Details
Main Authors: Katalin Sas, Hermina Robotka, Éva Rózsa, Márta Ágoston, Gábor Szénási, Gábor Gigler, Máté Marosi, Zsolt Kis, Tamás Farkas, László Vécsei, József Toldi
Format: Article
Language:English
Published: Elsevier 2008-11-01
Series:Neurobiology of Disease
Subjects:
Ischemia
Kynurenine
Kynurenic acid
Hippocampus
CA1
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001678

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http://www.sciencedirect.com/science/article/pii/S0969996108001678

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