Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice

Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice

Pelvic and abdominal radiotherapy plays an important role in eradication of malignant cells; however, it also results in slight intestinal injury. The apoptosis of cells in the intestinal epithelium is a primary pathological factor that initiates radiation-induced intestinal injury. Auranofin, a gol...

Full description

Bibliographic Details
Main Authors: Eun Sang Lee, Joong Sun Kim, Hyounji Lee, Jee-Yeon Ryu, Hae-June Lee, Jong Kyung Sonn, Young-Bin Lim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
auranofin
intestinal mucosa
apoptosis
oxidative stress
thioredoxin reductase
radiosensitivity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00417/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00417/full

Similar Items