Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response

Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response

Abstract Background Adoptive T-cell therapy (ACT) using autologous tumor-reactive T lymphocytes has considerable potential for cancer immunotherapy. In ACT, T cells are isolated from cancer patients and then stimulated and expanded in vitro by cytokines and costimulatory molecules. 4-1BB is an impor...

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Bibliographic Details
Main Authors: Salman Bagheri, Elmira Safaie Qamsari, Mehdi Yousefi, Farhad Riazi-Rad, Zahra Sharifzadeh
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
4-1BB
Single-chain fragment antibody
T-cell therapy
Immunomodulation
T cell responses
Online Access:http://link.springer.com/article/10.1186/s11658-020-00219-8

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http://link.springer.com/article/10.1186/s11658-020-00219-8

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