APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency. APOL1 is a trypanolytic protein that co...

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Bibliographic Details
Main Authors: Anneli Cooper, Hamidou Ilboudo, V Pius Alibu, Sophie Ravel, John Enyaru, William Weir, Harry Noyes, Paul Capewell, Mamadou Camara, Jacqueline Milet, Vincent Jamonneau, Oumou Camara, Enock Matovu, Bruno Bucheton, Annette MacLeod
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
Trypanosoma brucei
chronic kidney disease
Human African trypanosomiasis
sleeping sickness
Trypanosoma brucei gambiense
Trypanosoma brucei rhodesiense
Online Access:https://elifesciences.org/articles/25461

Internet

https://elifesciences.org/articles/25461

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