An improved LC-MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study☆

An improved LC-MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study☆

A highly sensitive and selective high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of alverine (ALV) and its active metabolite, para hydroxy alverine (PHA), in human plasma. For sample preparation, solid phase extraction of anal...

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Bibliographic Details
Main Authors: Dhiraj M. Rathod, Keyur R. Patel, Hiren N. Mistri, Arvind G. Jangid, Pranav S. Shrivastav, Mallika Sanyal
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Alverine
Para hydroxy alverine
Liquid chromatography-tandem mass spectrometry
Bioequivalence study
Human plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177916301228

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http://www.sciencedirect.com/science/article/pii/S2095177916301228

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