Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

Summary: An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by vaccination. Several HIV-1 envelope-derived germlin...

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Bibliographic Details
Main Authors: Emilie Seydoux, Yu-Hsin Wan, Junli Feng, Abigail Wall, Safia Aljedani, Leah J. Homad, Anna J. MacCamy, Connor Weidle, Matthew D. Gray, Lauren Brumage, Justin J. Taylor, Marie Pancera, Leonidas Stamatatos, Andrew T. McGuire
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
HIV-1
vaccines
anti-idiotypic antibodies
broadly neutralizing antibodies
B cell receptor
antibody light chain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004174

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http://www.sciencedirect.com/science/article/pii/S2211124721004174

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