Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

Extracellular vesicles (EVs) shed by trypomastigote forms of Trypanosoma cruzi have the ability to interact with host tissues, increase invasion, and modulate the host innate response. In this study, EVs shed from T. cruzi or T.cruzi-infected macrophages were investigated as immunomodulatory agents...

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Bibliographic Details
Main Authors: André Cronemberger-Andrade, Patrícia Xander, Rodrigo Pedro Soares, Natália Lima Pessoa, Marco Antônio Campos, Cameron C. Ellis, Brian Grajeda, Yifat Ofir-Birin, Igor Correia Almeida, Neta Regev-Rudzki, Ana Claudia Torrecilhas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
toll-like receptor 2
inflammation
extracellular vesicles
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00099/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00099/full

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