Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance

Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance

A typical inflammatory response sequentially progresses from pro-inflammatory, immune suppressive to inflammatory repairing phases. Although the physiological inflammatory response resolves in time, severe acute inflammation usually sustains immune tolerance and leads to high mortality, yet the unde...

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Bibliographic Details
Main Authors: Jingpu Zhang, Jie Tao, Yun Ling, Feng Li, Xuewei Zhu, Li Xu, Mei Wang, Shuye Zhang, Charles E. McCall, Tie Fu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
inflammation
immune tolerance
NAD biosynthesis pathways
indoleamine 2
3-dioxygenase
SIRT1-RelB axis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02358/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02358/full

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