Human Rab7 mutation mimics features of Charcot–Marie–Tooth neuropathy type 2B in Drosophila

Human Rab7 mutation mimics features of Charcot–Marie–Tooth neuropathy type 2B in Drosophila

Charcot–Marie–Tooth disease type 2B (CMT2B) is an inherited axonal peripheral neuropathy. It is characterised by prominent sensory loss, often complicated by severe ulcero-mutilations of toes or feet, and variable motor involvement. Missense mutations in RAB7A, the gene encoding the small GTPase Rab...

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Bibliographic Details
Main Authors: Katrien Janssens, Sofie Goethals, Derek Atkinson, Biljana Ermanoska, Erik Fransen, Albena Jordanova, Michaela Auer-Grumbach, Bob Asselbergh, Vincent Timmerman
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Rab7
Drosophila melanogaster
Charcot–Marie–Tooth
Behavioural assay
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000357

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http://www.sciencedirect.com/science/article/pii/S0969996114000357

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