Central glucocorticoid administration promotes weight gain and increased 11β-hydroxysteroid dehydrogenase type 1 expression in white adipose tissue.

Central glucocorticoid administration promotes weight gain and increased 11β-hydroxysteroid dehydrogenase type 1 expression in white adipose tissue.

Glucocorticoids (GCs) are involved in multiple metabolic processes, including the regulation of insulin sensitivity and adipogenesis. Their action partly depends on their intracellular activation by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). We previously demonstrated that central GC admini...

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Bibliographic Details
Main Authors: Christelle Veyrat-Durebex, Nicolas Deblon, Aurélie Caillon, Ruth Andrew, Jordi Altirriba, Alex Odermatt, Françoise Rohner-Jeanrenaud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316512?pdf=render

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http://europepmc.org/articles/PMC3316512?pdf=render

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