Recruitment to the nuclear periphery can alter expression of genes in human cells.
The spatial organisation of the genome in the nucleus has a role in the regulation of gene expression. In vertebrates, chromosomal regions with low gene-density are located close to the nuclear periphery. Correlations have also been made between the transcriptional state of some genes and their loca...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-03-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2265557?pdf=render |