Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Abstract Background Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related to abnormal calcium handling and energetic failure i...

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Bibliographic Details
Main Authors: Omar Lozano, Christian Silva-Platas, Héctor Chapoy-Villanueva, Baruc E. Pérez, Jarmon G. Lees, Chrishan J. A. Ramachandra, Flavio F. Contreras-Torres, Anay Lázaro-Alfaro, Estefanía Luna-Figueroa, Judith Bernal-Ramírez, Aldemar Gordillo-Galeano, Alfredo Benitez, Yuriana Oropeza-Almazán, Elena C. Castillo, Poh Ling Koh, Derek J. Hausenloy, Shiang Y. Lim, Gerardo García-Rivas
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Particle and Fibre Toxicology
Subjects:
Mitochondria
Silica nanoparticles
Oxidative stress
Cardiotoxicity
Permeability transition
Heart
Online Access:http://link.springer.com/article/10.1186/s12989-020-00346-2

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http://link.springer.com/article/10.1186/s12989-020-00346-2

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