A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.

A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.

Cells and tissues are exposed to stress from numerous sources. Senescence is a protective mechanism that prevents malignant tissue changes and constitutes a fundamental mechanism of aging. It can be accompanied by a senescence associated secretory phenotype (SASP) that causes chronic inflammation. W...

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Bibliographic Details
Main Authors: Patrick Meyer, Pallab Maity, Andre Burkovski, Julian Schwab, Christoph Müssel, Karmveer Singh, Filipa F Ferreira, Linda Krug, Harald J Maier, Meinhard Wlaschek, Thomas Wirth, Hans A Kestler, Karin Scharffetter-Kochanek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1005741

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https://doi.org/10.1371/journal.pcbi.1005741

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