Sterigmatocystin, 5-Methoxysterigmatocistin, and Their Combinations are Cytotoxic and Genotoxic to A549 and HepG2 Cells and Provoke Phosphorylation of Chk2, but not FANCD2 Checkpoint Proteins

Sterigmatocystin, 5-Methoxysterigmatocistin, and Their Combinations are Cytotoxic and Genotoxic to A549 and HepG2 Cells and Provoke Phosphorylation of Chk2, but not FANCD2 Checkpoint Proteins

Sterigmatocystin (STC) and 5-methoxysterigmatocystin (5-M-STC) are structurally related mycotoxins with cytotoxic and genotoxic properties. In the present study, we hypothesized that DNA damage induced by non-cytotoxic concentrations of single and combined mycotoxins could alter the phosphorylation...

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Bibliographic Details
Main Authors: Sanja Dabelić, Domagoj Kifer, Daniela Jakšić, Nevenka Kopjar, Maja Šegvić Klarić
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Toxins
Subjects:
Sterigmatocystin
5-methoxysterigmatocystin
checkpoint proteins
cytotoxicity
genotoxicity
mycotoxin interactions
Online Access:https://www.mdpi.com/2072-6651/13/7/464

Internet

https://www.mdpi.com/2072-6651/13/7/464

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