NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate

NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate

Summary Embryonic Stem (ES) cells are able to give rise to the three germ layers of the embryo but are prevented from contributing to the trophoblast. The molecular nature of this barrier between embryonic and trophectodermal cell fates is not clear, but is known to involve DNA methylation. Here we...

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Bibliographic Details
Main Authors: Paulina A. Latos, Christine Helliwell, Olukunbi Mosaku, Dominika A. Dudzinska, Bryony Stubbs, Maria Berdasco, Manel Esteller, Brian Hendrich
Format: Article
Language:English
Published: The Company of Biologists 2012-02-01
Series:Biology Open
Subjects:
Stem cells
NuRD
DNA methylation
Trophectoderm
Chromatin
Online Access:http://bio.biologists.org/content/1/4/341

Internet

http://bio.biologists.org/content/1/4/341

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