Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450

Cytochromes P450 (CYPs) metabolize polyunsaturated long-chain fatty acids (PUFA-LC) to several classes of oxygenated metabolites. Through use of human recombinant CYPs, we recently showed that CYP1A1, -2C19, -2D6, -2E1, and -3A4 are mainly hydroxylases, whereas CYP1A2, -2C8, -2C9, and -2J2 are mainl...

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Bibliographic Details
Main Authors: Danièle Lucas, Sophie Goulitquer, Jan Marienhagen, Maude Fer, Yvonne Dreano, Ulrich Schwaneberg, Yolande Amet, Laurent Corcos
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Journal of Lipid Research
Subjects:
regioselectivity
arachidonic acid
eicospentaenoic acid
docosahexaenoic acid
CYP102A1 F87V
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410685

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http://www.sciencedirect.com/science/article/pii/S0022227520410685

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