Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Lewy bodies and neurites, the pathological signatures found in the central nervous system of Parkinson's disease (PD) patients, are primarily composed of aggregated alpha-synuclein (aSyn). The observation that aSyn aggregates are also found in the enteric nervous system has prompted several stu...

Full description

Bibliographic Details
Main Authors: Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Neurobiology of Disease
Subjects:
Alpha-synuclein
Parkinson's disease
Protein misfolding cyclic amplification
Gut
Enteric nervous system
Biopsy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301172

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119301172

Similar Items