A Regulatory Loop of FBXW7-MYC-PLK1 Controls Tumorigenesis of MYC-Driven Medulloblastoma

A Regulatory Loop of FBXW7-MYC-PLK1 Controls Tumorigenesis of MYC-Driven Medulloblastoma

Polo-like kinase 1 (<i>PLK1</i>) is highly expressed in group 3 medulloblastoma (MB), and it has been preclinically validated as a cancer therapeutic target in medulloblastoma. Here, we demonstrate that PLK1 inhibition with PCM-075 or BI6727 significantly reduces the growth of MB cells a...

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Bibliographic Details
Main Authors: Dong Wang, Angela Pierce, Bethany Veo, Susan Fosmire, Etienne Danis, Andrew Donson, Sujatha Venkataraman, Rajeev Vibhakar
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
FBXW7
MYC
PLK1 inhibition
medulloblastoma
Online Access:https://www.mdpi.com/2072-6694/13/3/387

Internet

https://www.mdpi.com/2072-6694/13/3/387

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