Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice[S]
Hepatic VLDL overproduction is a characteristic feature of diabetes and an important contributor to diabetic dyslipidemia. Hepatic sortilin 1 (Sort1), a cellular trafficking receptor, is a novel regulator of plasma lipid metabolism and reduces plasma cholesterol and triglycerides by inhibiting hepat...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-10-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520353013 |