Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection

Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection

Abstract Background Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC) and Lewis (Le) determinants. The aim of this study was to evaluate...

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Bibliographic Details
Main Authors: Weronika Gonciarz, Maria Walencka, Anthony P. Moran, Krzysztof Hinc, Michał Obuchowski, Magdalena Chmiela
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Biomedical Science
Subjects:
MUC5AC
LewisX/Y
H. pylori
Guinea pigs
Online Access:http://link.springer.com/article/10.1186/s12929-019-0515-z

Internet

http://link.springer.com/article/10.1186/s12929-019-0515-z

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