Low dose gemcitabine increases the cytotoxicity of human Vγ9Vδ2 T cells in bladder cancer cells in vitro and in an orthotopic xenograft model

Low dose gemcitabine increases the cytotoxicity of human Vγ9Vδ2 T cells in bladder cancer cells in vitro and in an orthotopic xenograft model

Human γδT cell immunotherapy is well tolerated and has shown promising results in clinical trials; however, its antitumor efficacy is limited, including results in solid tumors. Ex-vivo expanded γδT cell stimulated by zoledronic acid (ZOL) activates the γδT cell subpopulation of so called Vγ9Vδ2 T c...

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Bibliographic Details
Main Authors: Teruki Shimizu, Mako Tomogane, Masatsugu Miyashita, Osamu Ukimura, Eishi Ashihara
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
γδt cell
bladder instillation
chemo-immunotherapy
gemcitabine
mica/b
nkg2d
orthotopic xenograft model
vγ9vδ2 t cell
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1424671

Internet

http://dx.doi.org/10.1080/2162402X.2018.1424671

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