Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization

Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization

The title compounds, (4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles, were prepared in four steps starting from commercially available 4-trifluoromethoxyaniline. The pyrrole (second ring) was added in one step using the Paal-Knorr method. The thiazole (third ring) was added...

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Bibliographic Details
Main Authors: Andrij O. Tolmachov, Oleksandr M. Pinchuk, Mykhaylo V. Vovk, Andrei A. Gakh
Format: Article
Language:English
Published: MDPI AG 2010-02-01
Series:Molecules
Subjects:
pyrrole
fluorinated heterocycles
Paal-Knorr reaction
trifluoromethoxy group
chain heterocyclization
Online Access:http://www.mdpi.com/1420-3049/15/2/997/

Internet

http://www.mdpi.com/1420-3049/15/2/997/

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