The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation.

The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation.

Post-transcriptional regulatory mechanisms are of fundamental importance to form robust genetic networks, but their roles in stem cell pluripotency remain poorly understood. Here, we use freshwater planarians as a model system to investigate this and uncover a role for CCR4-NOT mediated deadenylatio...

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Bibliographic Details
Main Authors: Jordi Solana, Chiara Gamberi, Yuliana Mihaylova, Stefanie Grosswendt, Chen Chen, Paul Lasko, Nikolaus Rajewsky, A Aziz Aboobaker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3868585?pdf=render

Internet

http://europepmc.org/articles/PMC3868585?pdf=render

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