Identification of CRYAB<sup>+</sup> KCNN3<sup>+</sup> SOX9<sup>+</sup> Astrocyte-Like and EGFR<sup>+</sup> PDGFRA<sup>+</sup> OLIG1<sup>+</sup> Oligodendrocyte-Like Tumoral Cells in Diffuse IDH1-Mutant Gliomas and Implication of NOTCH1 Signalling in Their Genesis

Identification of CRYAB<sup>+</sup> KCNN3<sup>+</sup> SOX9<sup>+</sup> Astrocyte-Like and EGFR<sup>+</sup> PDGFRA<sup>+</sup> OLIG1<sup>+</sup> Oligodendrocyte-Like Tumoral Cells in Diffuse IDH1-Mutant Gliomas and Implication of NOTCH1 Signalling in Their Genesis

Diffuse grade II IDH−mutant gliomas are slow−growing brain tumors that progress into high−grade gliomas. They present intratumoral cell heterogeneity, and no reliable markers are available to distinguish the different cell subtypes. The molecular mechanisms underlying the formation of this cell dive...

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Bibliographic Details
Main Authors: Meera Augustus, Donovan Pineau, Franck Aimond, Safa Azar, Davide Lecca, Frédérique Scamps, Sophie Muxel, Amélie Darlix, William Ritchie, Catherine Gozé, Valérie Rigau, Hugues Duffau, Jean-Philippe Hugnot
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
brain tumors
diffuse grade II IDH−mutant glioma
diffuse IDH1−mutant gliomas
cellular heterogeneity
NOTCH1 pathway
BMP
Online Access:https://www.mdpi.com/2072-6694/13/9/2107

Internet

https://www.mdpi.com/2072-6694/13/9/2107

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