L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis

L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis

Summary: Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination (HR) and arrest cell cycle. However, it remains ambiguous whether and how their E3 ligase activity regulates HR. Here, we demonstrate th...

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Bibliographic Details
Main Authors: Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Zeguang Han, William T. Pu, Sun Chen, Yingwei Chen, Kun Sun, Baoxie Ge, Bing Zhang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
BRCA1
DNA repair
DNA damage response
breast cancer
LARP7
therapy resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309554

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http://www.sciencedirect.com/science/article/pii/S2211124720309554

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