Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Background/Aims: Osteosarcoma is the second highest cause of cancer-related death in children and adolescents. Majority of osteosarcoma patients (90%) show metastasis. Previous reports revealed that osthole showed antitumor activities via induction of apoptosis and inhibition of proliferation. Howev...

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Bibliographic Details
Main Authors: Lu Wang, Lei Yang, Ying Lu, Yingzhun Chen, Tianhua Liu, Yanli Peng, Yuhong Zhou, Yang Cao, Zhenggang Bi, Tianyi Liu, Zhenhong Liu, Hongli Shan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Osthole
Osteosarcoma
PTEN/Akt
Tumor suppressor
Cell cycle
Migration and invasion
Online Access:http://www.karger.com/Article/FullText/445573

Internet

http://www.karger.com/Article/FullText/445573

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