Stochastic Model of Acidification, Activation of Hemagglutinin and Escape of Influenza Viruses from an Endosome

Stochastic Model of Acidification, Activation of Hemagglutinin and Escape of Influenza Viruses from an Endosome

Influenza viruses enter the cell inside an endosome. During the endosomal journey, acidification triggers a conformational change of the virus spike protein hemagglutinin (HA) that results in escape of the viral genome from the endosome into the cytoplasm. It is still unclear how the interplay betwe...

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Bibliographic Details
Main Authors: Thibault Lagache, Christian Sieben, Tim Meyer, Andreas Herrmann, David Holcman
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physics
Subjects:
modeling
first passage time
asymptotic analysis
conformational change
endosomal acidification
influenza virus
Online Access:http://journal.frontiersin.org/article/10.3389/fphy.2017.00025/full

Internet

http://journal.frontiersin.org/article/10.3389/fphy.2017.00025/full

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