Ribosome Pausing at Inefficient Codons at the End of the Replicase Coding Region Is Important for Hepatitis C Virus Genome Replication

Ribosome Pausing at Inefficient Codons at the End of the Replicase Coding Region Is Important for Hepatitis C Virus Genome Replication

Hepatitis C virus (HCV) infects liver cells and often causes chronic infection, also leading to liver cirrhosis and cancer. In the cytoplasm, the viral structural and non-structural (NS) proteins are directly translated from the plus strand HCV RNA genome. The viral proteins NS3 to NS5B proteins con...

Full description

Bibliographic Details
Main Authors: Gesche K. Gerresheim, Carolin S. Hess, Lyudmila A. Shalamova, Markus Fricke, Manja Marz, Dmitri E. Andreev, Ivan N. Shatsky, Michael Niepmann
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
HCV
translation
ribosome pausing
rare codon
Wobble codon
replication
Online Access:https://www.mdpi.com/1422-0067/21/18/6955

Internet

https://www.mdpi.com/1422-0067/21/18/6955

Similar Items