Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates Fos Gene Expression and Alters Behaviors in Male Mouse Offspring

Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates Fos Gene Expression and Alters Behaviors in Male Mouse Offspring

Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects and other birth defects. After 20 years mandate food fortification with FA, serum concentration of folate and unmetabolized FA increased significantly in the North American population. But whether excess F...

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Bibliographic Details
Main Authors: Dandan Chu, Longfei Li, Yanli Jiang, Jianxin Tan, Jie Ji, Yongli Zhang, Nana Jin, Fei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
folic acid
pregnancy
lactation
RNA sequencing
Fos
behavior
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00313/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00313/full

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