Interactions between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl<sup>−</sup>-Transport Shape Activity-Dependent Changes of Intracellular Cl<sup>−</sup> Concentration

Interactions between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl<sup>−</sup>-Transport Shape Activity-Dependent Changes of Intracellular Cl<sup>−</sup> Concentration

The effects of ionotropic &#947;-aminobutyric acid receptor (GABA-A, GABA<sub>A</sub>) activation depends critically on the Cl<sup>&#8722;</sup>-gradient across neuronal membranes. Previous studies demonstrated that the intracellular Cl<sup>&#8722;</sup&g...

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Bibliographic Details
Main Authors: Aniello Lombardi, Peter Jedlicka, Heiko J. Luhmann, Werner Kilb
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
development
hippocampus
CA3
Cl<sup>−</sup>-homeostasis
giant depolarizing potentials
ionic plasticity
computational neuroscience
Na<sup>+</sup>-K<sup>+</sup>-Cl<sup>−</sup>-Cotransporter, Isoform 1 (NKCC1)
mouse
Online Access:https://www.mdpi.com/1422-0067/20/6/1416

Internet

https://www.mdpi.com/1422-0067/20/6/1416

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