A Practical and Total Synthesis of Pasireotide: Synthesis of Cyclic Hexapeptide via a Three-Component Condensation

A Practical and Total Synthesis of Pasireotide: Synthesis of Cyclic Hexapeptide via a Three-Component Condensation

Pasireotide is a multi-receptor ligand somatostatin analogue approved for medical treatment of Cushing&#8217;s disease and acromegaly. The liquid-phase total synthesis of pasireotide-a 18-membered cyclic hexapeptide-was achieved by the 3 + 2 + 1 strategy, and the Pro<sup>1</sup>-Phe&...

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Bibliographic Details
Main Authors: Chunying Ma, Miao Chen, Weiming Chu, Jiayi Tao, Delong Kong, Mengmeng Zhang, Wenhua Feng
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
pasireotide
liquid-phase
synthesis
BSA/NHS
cyclic hexapeptide
Online Access:https://www.mdpi.com/1420-3049/24/11/2185

Internet

https://www.mdpi.com/1420-3049/24/11/2185

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