Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells

Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells

Abstract Background Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK...

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Bibliographic Details
Main Authors: Lindsey R. Conroy, Pawel Lorkiewicz, Liqing He, Xinmin Yin, Xiang Zhang, Shesh N. Rai, Brian F. Clem
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cancer Cell International
Subjects:
RB
Palbociclib
Metabolism
Glutaminolysis
PPP
Lung cancer
Online Access:http://link.springer.com/article/10.1186/s12935-020-01357-x

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http://link.springer.com/article/10.1186/s12935-020-01357-x

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