Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level

Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level

Folded proteins show a high degree of structural order and undergo (fairly constrained) collective motions related to their functions. On the other hand, intrinsically disordered proteins (IDPs), while lacking a well-defined three-dimensional structure, do exhibit some structural and dynamical order...

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Bibliographic Details
Main Authors: Xingcheng Lin, Prakash Kulkarni, Federico Bocci, Nicholas P. Schafer, Susmita Roy, Min-Yeh Tsai, Yanan He, Yihong Chen, Krithika Rajagopalan, Steven M. Mooney, Yu Zeng, Keith Weninger, Alex Grishaev, José N. Onuchic, Herbert Levine, Peter G. Wolynes, Ravi Salgia, Govindan Rangarajan, Vladimir Uversky, John Orban, Mohit Kumar Jolly
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Biomolecules
Subjects:
PAGE4
intrinsically disordered proteins
conformational plasticity
order–disorder transition
phosphorylation
Online Access:https://www.mdpi.com/2218-273X/9/2/77

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https://www.mdpi.com/2218-273X/9/2/77

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