Identification of Novel CDH1-NRG2α and F11R-NRG2α Fusions in NSCLC Plus Additional Novel NRG2α Fusions in Other Solid Tumors by Whole Transcriptome Sequencing

Identification of Novel CDH1-NRG2α and F11R-NRG2α Fusions in NSCLC Plus Additional Novel NRG2α Fusions in Other Solid Tumors by Whole Transcriptome Sequencing

Introduction: A novel CD74-NRG2α fusion has recently been identified in NSCLC. We surveyed a large tumor database comprehensively profiled by whole transcriptome sequencing to investigate the incidence and distribution of NRG2 fusions among various solid tumors. Methods: Tumor samples submitted for...

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Bibliographic Details
Main Authors: Sai-Hong Ignatius Ou, MD, PhD, Joanne Xiu, PhD, Misako Nagasaka, MD, Bing Xia, MD, Shannon S. Zhang, MD, Qing Zhang, PhD, Jeffrey J. Swensen, PhD, David Spetzler, MS, PhD, MBA, Wolfgang Michael Korn, MD, Viola W. Zhu, MD, PhD, Stephen V. Liu, MD
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:JTO Clinical and Research Reports
Subjects:
NRG2 fusion
CDH1-NRG2α
F11R-NRG2α
Whole transcriptome sequencing
ligand-fusion- positive malignancies
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364320301831

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http://www.sciencedirect.com/science/article/pii/S2666364320301831

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