Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina.
Functional inactivation of the Retinoblastoma (pRB) pathway is an early and obligatory event in tumorigenesis. The importance of pRB is usually explained by its ability to promote cell cycle exit. Here, we demonstrate that, independently of cell cycle exit control, in cooperation with the Hippo tumo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-04-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2858677?pdf=render |