Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells.

Humanized mouse models offer a challenging possibility to study human cell function in vivo. In the huPBL-SCID-huSkin allograft model human skin is transplanted onto immunodeficient mice and allowed to heal. Thereafter allogeneic human peripheral blood mononuclear cells are infused intra peritoneall...

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Bibliographic Details
Main Authors:	Vivian L de Oliveira, Romy R M C Keijsers, Peter C M van de Kerkhof, Marieke M B Seyger, Esther Fasse, Lars Svensson, Markus Latta, Hanne Norsgaard, Tord Labuda, Pieter Hupkens, Piet E J van Erp, Irma Joosten, Hans J P M Koenen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3477148?pdf=render

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http://europepmc.org/articles/PMC3477148?pdf=render

Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells.

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