CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity

CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity

Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established roles in the transcriptional regulation of genes...

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Bibliographic Details
Main Authors: Alexandra D. Rusu, Zoe E. Cornhill, Brenda Canales Coutiño, Marcos Castellanos Uribe, Anbarasu Lourdusamy, Zsuzsa Markus, Sean T. May, Ruman Rahman, Marios Georgiou
Format: Article
Language:English
Published: The Royal Society 2021-09-01
Series:Open Biology
Subjects:
cancer
tumour suppressor
invasion
Drosophila melanogaster
cell–cell junctions
ING1
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210077

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.210077

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