PLZF-RAR<sub>α</sub>, NPM1-RAR<sub>α</sub>, and Other Acute Promyelocytic Leukemia Variants: The PETHEMA Registry Experience and Systematic Literature Review

PLZF-RAR<sub>α</sub>, NPM1-RAR<sub>α</sub>, and Other Acute Promyelocytic Leukemia Variants: The PETHEMA Registry Experience and Systematic Literature Review

It has been suggested that 1–2% of acute promyelocytic leukemia (APL) patients present variant rearrangements of retinoic acid receptor alpha (RARα) fusion gene, with the promyelocytic leukaemia zinc finger (PLZF)/RAR<sub>α</sub> being the most frequent. Resistance to all-trans-retinoic...

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Bibliographic Details
Main Authors: Marta Sobas, Maria Carme Talarn-Forcadell, David Martínez-Cuadrón, Lourdes Escoda, María J. García-Pérez, Jose Mariz, María J. Mela-Osorio, Isolda Fernández, Juan M. Alonso-Domínguez, Javier Cornago-Navascués, Gabriela Rodríguez-Macias, María E. Amutio, Carlos Rodríguez-Medina, Jordi Esteve, Agnieszka Sokół, Thais Murciano-Carrillo, María J. Calasanz, Manuel Barrios, Eva Barragán, Miguel A. Sanz, Pau Montesinos
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
variant
acute promyelocytic leukemia
systematic review
characteristics
outcomes
Online Access:https://www.mdpi.com/2072-6694/12/5/1313

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https://www.mdpi.com/2072-6694/12/5/1313

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