Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients

Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients

Abstract Background CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active disease in SLE patients. In this study, we aimed to find the role of...

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Bibliographic Details
Main Authors: Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier, Andrea Steinborn
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus
T-helper cell differentiation
Regulatory T cells
Proliferation capacity
Immunosuppressive therapy
Online Access:http://link.springer.com/article/10.1186/s13075-018-1778-6

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http://link.springer.com/article/10.1186/s13075-018-1778-6

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