In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections

In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections

Monoclonal antibodies (mAbs) have wide clinical utility, but global access is limited by high costs and impracticalities associated with repeated passive administration. Here, we describe an optimized electroporation-based DNA gene transfer platform technology that can be utilized for production of...

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Bibliographic Details
Main Authors: Chasity D. Andrews, Yang Luo, Ming Sun, Jian Yu, Arthur J. Goff, Pamela J. Glass, Neal N. Padte, Yaoxing Huang, David D. Ho
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
plasmid
DNA-based antibody gene transfer
electroporation
infectious disease
influenza
Ebola
Online Access:http://www.sciencedirect.com/science/article/pii/S232905011730102X

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http://www.sciencedirect.com/science/article/pii/S232905011730102X

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