Autosomal Dominant Retinitis Pigmentosa Due to Class B <i>Rhodopsin</i> Mutations: An Objective Outcome for Future Treatment Trials

Autosomal Dominant Retinitis Pigmentosa Due to Class B <i>Rhodopsin</i> Mutations: An Objective Outcome for Future Treatment Trials

Gene therapy for adRP due to <i>RHO</i> mutations was recently shown to prevent photoreceptor death in a canine model of Class B disease. Among translational steps to be taken, one is to determine a method to detect efficacy in a human clinical trial. The relatively slow progression of a...

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Bibliographic Details
Main Authors: Alexander Sumaroka, Artur V. Cideciyan, Jason Charng, Vivian Wu, Christian A. Powers, Bhavya S. Iyer, Brianna Lisi, Malgorzata Swider, Samuel G. Jacobson
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
optical coherence tomography
photoreceptors
retinal degeneration
rods
Online Access:https://www.mdpi.com/1422-0067/20/21/5344

Internet

https://www.mdpi.com/1422-0067/20/21/5344

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