Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

The development of the cardiac outflow tract (OFT), which connects the heart to the great arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle (SMCs) cells. Defects in OFT development can lead to severe malformations, including aortic aneurysms, which are frequently as...

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Bibliographic Details
Main Authors: Giulia LM Boezio, Anabela Bensimon-Brito, Janett Piesker, Stefan Guenther, Christian SM Helker, Didier YR Stainier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
outflow tract
TGF-β
Endothelium
smooth muscle cells
cellular cross-talk
extracellular matrix
Online Access:https://elifesciences.org/articles/57603

Internet

https://elifesciences.org/articles/57603

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