Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.

Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.

The majority of renal cell carcinomas (RCCs) are characterized by loss of function of the tumor suppressor gene von Hippel Lindau (VHL), which acts as ubiquitin ligase for hypoxia-inducible factor-1α (HIF-1α). In the absence of VHL, HIF-1α protein becomes stabilized and contributes to tumorigenesis....

Full description

Bibliographic Details
Main Authors: Lei Gao, Guo-jun Wu, Bei Liu, Ming-zhi Shen, Tie-jun Pan, Chui-gong Yu, Qin-hao Wang, Yi Ru, Xi-ping Liu, Tian-shui Niu, Guo-dong Wang, Ming Wei, Rui-xiao Li, Libo Yao, He Wang, Xia Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869857?pdf=render

Internet

http://europepmc.org/articles/PMC3869857?pdf=render

Similar Items