Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation

Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation

Background and Objective: Sphingosine 1-phosphate (S1P), and S1P receptor modulator fingolimod have been suggested to play important cardioprotective role in animal models of myocardial ischemia/reperfusion injuries. To understand the cardioprotective function of S1P and its mechanism in vivo, we an...

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Bibliographic Details
Main Authors: Naseer Ahmed, Daniele Linardi, Nazeer Muhammad, Cristiano Chiamulera, Guido Fumagalli, Livio San Biagio, Mebratu A. Gebrie, Muhammad Aslam, Giovanni Battista Luciani, Giuseppe Faggian, Alessio Rungatscher
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
sphingosine 1-phosphate
cardiac fibrosis
ischemia/reperfusion injury
cardioprotective
heart transplantation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00645/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00645/full

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