MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB

Abstract Background Deletions of 6q15–16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be fu...

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Bibliographic Details
Main Authors: David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik, Joachim B. Kunz
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
T-cell acute lymphoblastic leukemia
T-ALL
TGF-beta activated kinase 1
MAP3K7
chr6q15 deletion
Online Access:http://link.springer.com/article/10.1186/s12885-018-4525-0

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http://link.springer.com/article/10.1186/s12885-018-4525-0

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