Synthesis of Tetra‐Substituted Trifluoromethyl‐3,1‐Benzoxazines by Transition‐Metal‐Catalyzed Decarboxylative Cyclization of N‐Benzoyl Benzoxazinones

Synthesis of Tetra‐Substituted Trifluoromethyl‐3,1‐Benzoxazines by Transition‐Metal‐Catalyzed Decarboxylative Cyclization of N‐Benzoyl Benzoxazinones

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Abstract Efficient synthesis of N,O‐heterocyclic tetra‐substituted trifluoromethyl‐3,1‐benzoxazines via a transition‐metal‐catalyzed decarboxylative intramolecular cyclization was achieved. The decarboxylation of N‐benzoyl trifluoromethyl‐benzoxazinones generated the amide oxygen nucleophile, allowi...

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Bibliographic Details
Main Authors: Hiroto Uno, Daichi Fujimoto, Kyosuke Harada, Chika Tanaka, Prof. Dr. Norio Shibata
Format: Article
Language:English
Published: Wiley-VCH 2021-05-01
Series:ChemistryOpen
Subjects:
Benzoxazinones
copper
decarboxylation reactions
fluorinated compounds
heterocycle derivatives
intramolecular cyclization reactions
Online Access:https://doi.org/10.1002/open.202000360

Internet

https://doi.org/10.1002/open.202000360

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