Inhibition of P2X7 Purinergic Receptor Ameliorates Fibromyalgia Syndrome by Suppressing NLRP3 Pathway

Inhibition of P2X7 Purinergic Receptor Ameliorates Fibromyalgia Syndrome by Suppressing NLRP3 Pathway

Fibromyalgia is a chronic condition characterized by persistent widespread pain that significantly reduces quality of life in patients. The purinergic P2X7 receptor (P2X7R) seems to be involved in different pain states and neuroinflammation. The purpose of this study is to investigate the positive e...

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Bibliographic Details
Main Authors: Ramona D’Amico, Roberta Fusco, Rosalba Siracusa, Daniela Impellizzeri, Alessio Filippo Peritore, Enrico Gugliandolo, Livia Interdonato, Andrea Maria Sforza, Rosalia Crupi, Salvatore Cuzzocrea, Tiziana Genovese, Marika Cordaro, Rosanna Di Paola
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
fibromyalgia
P2X7 receptor
NLRP3 inflammasome
neuroinflammation
Online Access:https://www.mdpi.com/1422-0067/22/12/6471

Internet

https://www.mdpi.com/1422-0067/22/12/6471

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