Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

During screening of genes upregulated by lipopolysaccharide (LPS; endotoxin) treatment of bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-hydroxylase (Ch25h) was strongly upregulated. Treatment of macrophages with 10 ng/ml of LPS for 2 h resulted in a 35-fold inc...

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Bibliographic Details
Main Authors: Ulf Diczfalusy, Katarina E. Olofsson, Ann-Margreth Carlsson, Mei Gong, Douglas T. Golenbock, Olav Rooyackers, Urban Fläring, Harry Björkbacka
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Journal of Lipid Research
Subjects:
25-hydroxycholesterol
oxysterols
endotoxin
inflammation
sepsis
macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752030691X

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http://www.sciencedirect.com/science/article/pii/S002222752030691X

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