Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model

Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model

Adoptive cell therapy (ACT) using in vitro expanded tumor infiltrating T lymphocytes (TILs) from biopsy material represents a highly promising treatment of disseminated cancer. A crucial prerequisite for successful ACT is sufficient recruitment of transferred lymphocytes to the tumor site; however,...

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Bibliographic Details
Main Authors: Manja Idorn, Signe Koggersbøl Skadborg, Lauge Kellermann, Hólmfrídur Rósa Halldórsdóttir, Gitte Holmen Olofsson, Özcan Met, Per thor Straten
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:OncoImmunology
Subjects:
genetic engineering
adoptive cell therapy
act
t cells
chemokine receptor
cxcr2
il-8
malignant melanoma
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1450715

Internet

http://dx.doi.org/10.1080/2162402X.2018.1450715

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