In silico design of MHC class I high binding affinity peptides through motifs activation map

In silico design of MHC class I high binding affinity peptides through motifs activation map

Abstract Background Finding peptides with high binding affinity to Class I major histocompatibility complex (MHC-I) attracts intensive research, and it serves a crucial part of developing a better vaccine for precision medicine. Traditional methods cost highly for designing such peptides. The advanc...

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Bibliographic Details
Main Authors: Zhoujian Xiao, Yuwei Zhang, Runsheng Yu, Yin Chen, Xiaosen Jiang, Ziwei Wang, Shuaicheng Li
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Bioinformatics
Subjects:
Design new peptides with high binding affinity to MHC-I molecule
Convolutional neural network
Motifs activation map
Online Access:http://link.springer.com/article/10.1186/s12859-018-2517-3

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http://link.springer.com/article/10.1186/s12859-018-2517-3

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